Biochips refer to the complete fundamental functional unit, capable of performing multi biochemical tasks simultaneously. Tissue chips on the other hand are similar miniaturized units that can replace a tissue or some part of it, enabling the organ to work normally. Both biochips & tissue chips have been elemental in tissue engineering technology and have proven to be of utmost importance in the same arena. DNA microarray also called as biochip in simple terms consists of a two dimensional grid system where upon sensors or solid flat substrates are incorporated. These solid substrates can be either positively charged just like silicon or glass or can also be consisting of integrated circuitry units that perform best in signal transduction studies. Specific and simultaneous profiling of biological markers is probably the biggest advantage of this technology for clinical applications. Current clinical tests rely on the sensitive detection of small changes of analyte levels for accurate diagnosis and treatment. Manipulation of the biochip surface is required to reduce complex biochemical interference and enable ligand attachment at specific and discrete test sites.
Last date updated on July, 2014