Biofilm formation by fungal and bacterial pathogens on implanted medical devices causes major morbidity and mortality among patients, and leads to billions of dollars in healthcare cost. There are estimated to be more than 45 million medical devices implanted every year in the United States. Infection of these devices occurs in 60% of patients, and Candida species are responsible for up to 20% of these infections. Biofilms are complex structures are highly resistant to antimicrobial agents and the host immune system.
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Last date updated on June, 2014