Next-generation sequencing (NGS), the latest and most promising methodology for genome-wide analysis of DNA methylation, may be used as an alternative for DNA methylation analysis. Very large amounts of sequence information produced by NGS provide a quantitative measure of DNA methylation abundance. Meanwhile, sequencing-based analysis will increase the efficiency and resolution of the detection of DNA methylation as it may use less input DNA to obtain high coverage sequencing of whole genomes and avoid biases that affect hybridization such as sequence composition. Vs Jianzhong Su, Advances in Bioinformatics Tools for High-Throughput Sequencing Data of DNA Methylation
Last date updated on July, 2014
