Scholarly journals are generally academic journals that encourage academic and scientific research. These journals generally prefer to publish original works, conducted following a systematic research methodology. The articles published in the scholarly journals are critically evaluated following in-depth analysis of the research data. Scholarly Journal articles strictly adhere to a standard format of writing.
Once the author accomplishes their task of writing following the standard format and submits the manuscript for publication, it is the responsibility of the scholarly journal to verify whether it is written as per the academic and research norms. Scholarly journals hence subject like medical and clinical articles for a blind peer review or double peer review system and expect the authors to correct and resubmit the research articles as per the expert opinion. Scholarly journals thus expect the authors to sign the declaration, stating that the work is original and unpublished that duly acknowledges the sources referred for information.
Liver and kidney damage associated with polytrauma, endotoxic shock/sepsis, and organ transplantation, are among the leading causes of the multiple organ failure. Development of novel sensitive biomarkers that detect early stages of liver and kidney injury is vital for the effective diagnostics and treatment of these life-threatening conditions. Several hepatic proteins, including Argininosuccinate Synthase (ASS) and sulfotransferases which were degraded in the liver and rapidly released into circulation during Ischemia/Reperfusion (I/R) injury were identified. Sensitivity and specificity of the newly developed sandwich ELISA assays for ASS and the sulfotransferase isoform SULT2A1 with the standard clinical liver and kidney tests Alanine Aminotransferase (ALT) and Aspartate Transaminase (AST) in various pre-clinical models of acute injury were compared. Ideally, biomarkers should employ biological substrates unique to the organ and, at the same time, provide information on injury mechanisms, a criterion that is used to distinguish biochemical markers from surrogate markers of injury since surrogate markers usually do not provide information on injury mechanisms. Argininosuccinate Synthase (ASS) is a link between urea cycle and Nitric Oxide (NO) synthesis which plays a major role in responses to ischemia, oxidative stress and toxins upon activation of inducible NO synthase in hepatocytes. Thus, ASS and SULT2A1 have superior characteristics over traditional biomarkers for liver and kidney health assessment in endotoxemia, I/R, chemical and drug-induced liver injury and may be of high potential value for clinical applications. (Prima V, Cao M, I Svetlov S, ASS and SULT2A1 are Novel and Sensitive Biomarkers of Acute Hepatic Injury-A Comparative Study in Animal Models)
Last date updated on January, 2021