alexa Scholarly Open Access Journals In Bone Markers|Omics Group|Journal Of Molecular Biomarkers And Diagnosis

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Scholarly Open Access Journals In Bone Markers

Several different bone markers have been investigated to assist the diagnosis of bone turnover. However the accuracy of those markers does not allow being the only diagnostic instrument to predict the appearance of bone metastasis. So far none of the known markers could be solely used for a screening of patients to diagnose metastasis to bone. The usefulness of bone markers, respectively Alkaline Phosphatase (AP) and Tartrat Resistant Acid Phosphatase 5b (TRACP 5b) for diagnosis, treatment and monitoring of patients with carcinoma of different origin was investigated. Alkaline Phosphatase is a marker of bone formation, while TRACP 5b is a marker of bone resorption. The isoform 5b of the enzyme TRACP is expressed by osteoclasts and can be measured in blood. Objectives: The aim of this study was to evaluate the prognostic value of the bone markers AP and TRACP 5b to detect bone metastasis and pathological bone metabolism. Sera from the patients with tumor markers were collected and the bone markers AP and TRACP 5b were determined. In conclusion TRACP 5b is more sensitive and specific to detect bone metastasis and bone turnover than the Alkaline Phosphatase. In patients with multimorbidity the origin of AP is not clear due to its multiorganic appearance. The levels of TRACP 5b are elevated in patients with bone metastasis and in patients with chronical dysfunction of the liver. TRACP 5b might be helpful in the diagnostic procedure of tumor-patients to detect bone metastasis. Moreover TRACP 5b seems to be helpful to indicate oncological patients with early dysfunctions in bone metabolism and helps to induce early treatment to these patients. (Zulauf N, Speda MD, Oremek GM, Marzi I , Prognostic Value of Bone Markers in Patients with Carcinoma) Scholarly open access journals have emerged as an alternative to traditional subscription journals. Open access scholarly journals are available online to the reader without financial, legal, or technical barriers. Scholarly open access journals are journals which are respected for the extensive research and information they provide about the point. The research often possesses refereed meaning that it is reviewed by other scientists who are knowledgeable about the theme of the article. Scholarly open access journals cite their sources using references or bibliographies. OMICS Group International has 350 online scholarly open access journals and organizes 100 international conferences worldwide. Apart from providing a free access to articles to everyone, it also extends support to other scholarly journals in the peer-review process, production, and distribution. All the articles published in OMICS Group journals are peer reviewed and published only on adhering to the norms. Upon acceptance, the articles will be immediately and permanently free for everyone to read and download. OMICS Group International has established agreements with 100 scientific associations by covering some or all of the publication costs for their individual researchers. It has 30,000 eminent scientists support to ensure a rapid and quality review process within the stipulated time. OMICS journals are indexed in the reputed: database like PubMed Central and Scopus. OMICS Journals of Life Sciences, medical, clinical, chemistry, pharmaceutical, engineering, omics, environment, and management are known for a very high impact factor of Life Sciences, medical, clinical, chemistry, pharma, engineering, omics, environment, and management.
 
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