Several recent studies measured elevated levels of circulating plasma microRNAs (miRNAs) after toxicant-induced liver injury, most likely due to leakage from damaged hepatocytes. miRNAs have also been detected in urine with some of them being derived from organs outside of the urinary system, opening up their potential use as noninvasive biomarkers of disease or injury. Despite this potential, changes in urine miRNA profiles have not been investigated as biomarkers for drug-induced liver injury.miRNAs in the urine could reflect the severity of APAP-induced liver injury and therefore have the potential to be used as noninvasive preclinical and clinical biomarkers.In contrast to mRNA, miRNA is much more stable and has been found in intact form in various extracellular body fluids such as plasma and urine. Due to this stability, miRNAs have the potential to be used as noninvasive biomarkers. Further aiding their use as noninvasive urine biomarkers is the fact that the characterization and quantification processes of miRNAs are more specific and efficient than many protein biomarker.Urinary miRNA patterns would reflect the biological status of the liver after APAP exposure and could serve as biomarkers of injury.Using these methods, we illustrate that the aberrant pattern of urinary miRNAs can be used as noninvasive biomarkers of APAP-induced liver injury.(Xi Yang, Zhiguang Li, Zhenqiang Su, Kelly Davis, Tao Chen, Donna L Mendrick and William Salminen, Urinary Micrornas as Noninvasive Biomarkers for Acetaminophen- Induced Liver Injury)
OMICS Group International is a scientific organization that promotes open access for relevant scientific information and research findings. About 700+ peer-reviewed journals are handled by more than 25000 editorial board members who belong to both academic and industrial circles in all aspects of Science, Engineering, Management and Technology journals. A collaboration set up recently with 100 international societies would provide a window to wider knowledge-base of worldwide open access health-related information. As part of its drive to boost knowledge-sharing through real-time interaction, this open access group has been organizing over 100 world-class scientific conferences at global venues through the calendar year. Abstracts presented at the meets are invited from scholars with a track record of effective research papers that are also published as special journal issue for each of the conference. Apart from India and the US as established locations, the events would soon expand to several continents to add the regional touch through collaboration with scientific and healthcare bodies in respective geographies like Europe, Australia and the Middle East. Most of the international conferences comprise of day-long programs in the form of symposiums or workshops, which serve as a specialized program within the main event. Realizing the potential of open access in terms of greater visibility within and beyond the scientific community, in recent years, there has been a tremendous breakthrough to open access movement through various open access publishers. OMICS is one such publishing group that believes in this movement and is most ardently working towards the welfare and progress of scientific community.
Last date updated on July, 2014