Several recent studies measured elevated levels of circulating plasma microRNAs (miRNAs) after toxicant-induced liver injury, most likely due to leakage from damaged hepatocytes. miRNAs have also been detected in urine with some of them being derived from organs outside of the urinary system, opening up their potential use as noninvasive biomarkers of disease or injury. Despite this potential, changes in urine miRNA profiles have not been investigated as biomarkers for drug-induced liver injury.miRNAs in the urine could reflect the severity of APAP-induced liver injury and therefore have the potential to be used as noninvasive preclinical and clinical biomarkers.In contrast to mRNA, miRNA is much more stable and has been found in intact form in various extracellular body fluids such as plasma and urine. Due to this stability, miRNAs have the potential to be used as noninvasive biomarkers. Further aiding their use as noninvasive urine biomarkers is the fact that the characterization and quantification processes of miRNAs are more specific and efficient than many protein biomarker.Urinary miRNA patterns would reflect the biological status of the liver after APAP exposure and could serve as biomarkers of injury.Using these methods, we illustrate that the aberrant pattern of urinary miRNAs can be used as noninvasive biomarkers of APAP-induced liver injury.(Xi Yang, Zhiguang Li, Zhenqiang Su, Kelly Davis, Tao Chen, Donna L Mendrick and William Salminen, Urinary Micrornas as Noninvasive Biomarkers for Acetaminophen- Induced Liver Injury)
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Last date updated on July, 2021