Lung cancer is the most common cause of cancerârelated mortality worldwide in male and female. Many patients with lung cancer are in the advanced stages of the disease at the time of diagnosis. However, the poor early detection of lung cancer and ineffective treatments for advanced disease are responsible for the low overall 5-year survival rate of only 14% . Therefore, the development of noninvasive diagnostic tools for discovery of novel lung cancer specific biomarker is emerging as an important to identify early stage of lung cancer and therapeutic applications. Proteomic techniques including two-dimensional gel electrophoresis (2-DE) and differential gel electrophoresis coupled with MS technology are useful for the analysis of tumormarkers . Recently, different proteomic approaches have been used for biomarker discovery in urine samples of lung cancer patients . All of these studies have provided interesting data that contributed to enrich the urinary proteomic map of lung cancer patients. Tantipaiboonwong et al. studied urinary proteome changes between lung cancer patients and healthy controls by 2-DE. Several differentially expressed proteins were identified as potential biomarkers. To search for potential biomarkers of lung cancer, we systematically analyzed urinary proteins secreted from lung cancer patients and healthy donors. The human proteome is the entire set of proteins expressed by a genome, cell, tissue and organism at any given time. The proteome of an organism, tissue or even a single type of cells is much more complex than its corresponding genome. This is mostly due to alternate splicing, post-translational processing and different patterns of protein modification which affect virtually all proteins.Due to proteomes complexity, their analysis is extremely challenging. Therefore, it can potentially overcome some limitations of other approaches to identify new marker molecules for many diseases. Moreover, the proteins secreted from tumor cells are potential biomarkers for disease diagnosis and prognosis. (Potprommanee L, Ma HT, Chen CH, Aobchey P, Boonyapranai K,Human Urinary GM2-activator Protein as a Potential Biomarker for Lung Cancer)
About 700+ peer-reviewed journals are handled by more than 25000 editorial board members who belong to both academic and industrial circles in all aspects of Science, Engineering, Management and Technology journals. A collaboration set up recently with 100 international societies would provide a window to wider knowledge-base of worldwide open access health-related information. As part of its drive to boost knowledge-sharing through real-time interaction, this open access group has been organizing over 100 world-class scientific conferences at global venues through the calendar year. Abstracts presented at the meets are invited from scholars with a track record of effective research papers that are also published as special journal issue for each of the conference. Apart from India and the US as established locations, the events would soon expand to several continents to add the regional touch through collaboration with scientific and healthcare bodies in respective geographies like Europe, Australia and the Middle East.
Last date updated on July, 2014