Metabolomics is an emerging and powerful discipline that provides an accurate and dynamic picture of the phenotype of mammalian systems through the study of endogenous and exogenous metabolites in cells, and culture supernatants. It enables the characterization of endogenous molecules that are the products of biochemical reactions, revealing connections between different pathways in a living cell. More specifically, the ability to uncover and evaluate biochemical differences within healthy and diseased organisms provides information as to the underlying cause(s) of disease, which in turn suggests targets for pharmacological intervention. Aim of metabolomics analysis is to describe qualitatively and quantitatively the final products of cellular regulatory pathways and can be seen as the ultimate response of a biologic system to genetic factors and/or environmental changes. Cell metabolome can be defined as the set of all the metabolites present in cells and considered the best indicator of an organisms phenotype. Metabolomics will allow an objective assessment of the impact of candidate drugs on cells. This quantitative approach should help guide the development of new drugs reducing failure rates in clinical phase. Therefore, metabolomics was evaluated to rapidly and efficiently analyze cell-derived natural products. Metabolomics capitalizes on the small molecules in cell to construct a fingerprint that can be unique to the individual. Smallmolecule metabolites as primary indicators have an important role in biological systems and represent attractive candidates to understand cell phenotypes.
A journal is a periodical publication intended to further progress of science, usually by reporting new research. Most journals are highly specialized, although some of the oldest journals publish articles, reviews, editorials, short communications, letters, and scientific papers across a wide range of scientific fields. Journals contain articles that peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientific validity. Each such journal article becomes part of the permanent scientific record.
Last date updated on July, 2014