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The molecular mechanisms which contribute to the development of vascular events including cerebral vasospasm after subarachnoid hemorrhage (SAH) in cerebral artery remain to be elucidated. In this study, it was investigated that the time course of changes in the gene expression of cerebral artery using rabbit SAH model and performed bioinformatic analysis of differentially expressed genes. The gene microarray method allows simultaneous analysis of the expression of thousands of genes. This technology promises to allow investigation of the entire genome on a single chip so that researchers can obtain a global picture of the interactions among thousands of genes simultaneously. Cerebral vasospasm is thought to be a biologically complex and multifactorial pathological condition. Therefore, this new approach will produce a broad view of the pathological mechanisms by identifying pathogenic genes and their interaction in various functional networks. Moreover, analyzing chronological changes in gene expression of cerebral artery may be helpful for elucidating the mechanism of cerebral vasospasm because the delayed onset is a fundamental feature of the pathophysiology of cerebral vasospasm. (YuichiroKikkawa, Satoshi Matsuo, Masaaki Hokama, RyotaKurogi, Akira Nakamizo, Masahiro Mizoguchi and Tomio Sasaki, Gene Expression Profiling and Bioinformatic Analysis of Rabbit Basilar Artery after Experimental Subarachnoid Hemorrhage)
Last date updated on July, 2014