Protein Biomarker Journals

In both preclinical and clinical settings, Drug-Induced Kidney Injury (DIKI) including acute glomerular damage is often undetectable by non-invasive methods such as measurement of Serum Creatinine (sCr) or Blood Urea Nitrogen (BUN) concentrations which represent traditional renal biomarkers.The United States Food & Drug Administration (US FDA), European Medicines Agency (EMA) and Pharmaceuticals Medical Devices Agency, Japan (PMDA) have acknowledged the qualification of eight novel urinary protein biomarkers that are highly sensitive and specific for monitoring DIKI progression in rats.The qualified renal biomarkers include but are not limited to urinary Total Protein (uTP), urinary Albumin (uAlb) and urinary Kidney Injury Molecule 1 (uKIM 1).Stemming from the qualification of novel DIKI biomarkers in rats, it is paramount to further understand the value of multiplex measurement of urinary protein concentrations of uTP, uAlb, uKIM 1 and uOpn for monitoring early, acute glomerular injury with secondary renal tubular injury in rats. In this study, various traditional and novel protein biomarkers were evaluated to determine their sensitivity and specificity in the prediction of progressive, subclinical doxorubicin nephrotoxicity in male Sprague-Dawley rats.the feasibility of protein biomarkers in the prediction of subclinical doxorubicin nephrotoxicity was evaluated in male Sprague-Dawley rats [2-6]. Of the doses tested, only the doxorubicin (5 mg/kg/dose) and concurrent control (vehicle) group animals were evaluated for detection of novel renal biomarker concentration changes because higher doses of doxorubicin (7.5 and 10 mg/kg/dose) were associated with clinical signs of systemic toxicity and histopathology findings.(James Eric McDuffie, ManishaSonee, Jing Ma, Frederic Almy, Xuejun Liu, David La and Sandra Snook, Feasibility of Protein Biomarkers in the Prediction of Subclinical Doxorubicin Nephrotoxicity in Male Sprague-Dawley Rat)

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Last date updated on September, 2024