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Stilbenes are natural phenolic compounds which function as antimicrobial phytoalexins in plants and affect human health as cardioprotective, antibacterial, antioxidative and antineoplastic agents . In this review, the progresses of study on relevant enzymes, genes and regulation mechanism in biosynthesis pathway of stilbenes are described. Here we introduce a holistic and systematic method of researching relevant enzymes, genes and other regulatory factors in biosynthesis pathway of stilbenes - Systems biology. The application of knowledge of relative enzymes, genes and regulation mechanisms in stilbenes biosynthesis in metabolic engineering which is used as a tool of improving the disease resistance of plants and health caring quality of crops is also discussed. Now we have only a rudimentary grasp of the basic framework of the main plant secondary metabolic pathways such as alkaloids synthesis pathway, phenylpropanoid biosynthesis pathway and isoprenoid biosynthesis pathway, but lack of research on rate-limiting steps, related isozymes and specific biosynthesis pathways of specific secondary metabolite. Plant secondary metabolism is a complicated dynamic process which is regulated by plant genetic background and growth process, also affected by ecological environment and pathogen infection, insect feeding and stimulation of various elicitors. The induction expression of related genes and enzymes also need be further studied. Because of disease resistance and medicinal health functions of resveratrol, stilbene glucoside and other inducible stilbenes, secondary metabolic engineering can be used to increase the content of exogenous stilbenes in transgenic plants. However, the complexity of enzymes in biosynthesis pathway and regulation of gene expression increase the difficulty in researching metabolism genetic engineering of stilbenes.[Lu D, Zhao W, Zhu K, Zhao SJ (2012) Relevant Enzymes,Genes and Regulation Mechanisms in Biosynthesis Pathway of Stilbenes]
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Last date updated on June, 2014

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