There is no clear and simple way to perform viral validation studies in biocontainment facilities with BSL3 pathogens. The establishment of certain guidelines for viral inactivation with threshold standards of efficacy (>4 log10R), and the creation of a bank of potential viruses to be tested, would be highly advisable. When testing commercial nucleic acid extraction steps, minimum criteria (worst cases in reagent concentration, temperature or contact-times) should be determined in order to fully challenge the robustness of the step or reagent. It should also be mandatory to test the viruses actually in use within the facility.
Xavier Abad; Transfer of Biological Samples from a Biosafety Level 3 Facility
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Last date updated on July, 2014