alexa The Curses and the Blesses of E-Cadherin

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

The Curses and the Blesses of E-Cadherin

E-cadherin is an evolutionary conserved molecule expressing from lower level animal to human. The principal role of E-cadherin is to maintain appropriate cell-cell connectivity at adherensjunction. Besides its role as cell-cell connector protein, E-cadherin is integrally involved in intracellular signaling as well as cytoskeletal remodeling. Proper spaciotemporal regulations as well as relevant specialized functions of E-cadherin are important for maintaining normal embryogenesis, cellular morphology and physiological function. However, defects in the expression and function of this gene products could become curses since numerous genetic and developmental studies have identified the critical role of this gene in path physiological conditions of multiple types of cancers leading to fatality. Recent study identified essential role of this gene product in stem cell biology including normal embryogenesis, induced pluripotent stem cell (iPSC) generation and stem cell differentiation.

 

Citation:

Nag K, Sultana N, Akaike T (2014) The Curses and the Blesses of E-Cadherin. Human Genet Embryol 4:118.

 
  • Share this page
  • Facebook
  • Twitter
  • LinkedIn
  • Google+
  • Pinterest
  • Blogger
 
adwords