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The production of recombinant human proteins with pharmaceutical uses in the milk of transgenic animals is sometimes referred to as “gene pharmingâ€Ã¯Â¿Â½. This technology can overcome the limitations facing traditional recombinant pharmaceutical protein production systems. The mammary gland is the preferred protein production site, due to the quantities of protein that can be produced. Based on a partnership with colleagues from the Russian Academy of Sciences, which had already obtained transgenic mice for hG-CSF, the idea was to use the same DNA construct for the production of transgenic goats secreting this recombinant protein into its milk. After DNA microinjection of in vivo produced pronuclear embryos was performed, two founders were obtained: one male and one female, named 10 M and 12 F, respectively
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