alexa New Perspectives on Epigenetic Inheritance

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New Perspectives on Epigenetic Inheritance

Epigenetic control by methylation is directly dependent on SAM/methionine. Free methionine aside from being used for protein synthesis is activated to universal methyl group donor SAM and the methyl group from it can be transferred mainly onto DNA, histones, mRNA and noncoding (Nc) RNA, in the nucleus and onto various cytosolic recipients by specific methyltransferases. The control of methylation and equally the demethylation is extremely crucial for epigenetic control mechanisms (gene suppression/expression) and any dysregulation would cause abnormal tissues/cancer.

 

Venkatachalam KV (2014) Methionine Metabolism in Humans: New Perspectives on Epigenetic Inheritance. J Mol Genet Med 8:138. doi: 10.4172/1747-0862.1000138

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