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Thrombomodulin, a 75 kDa glycoprotein, is a membrane protein expressed on the surface of endothelial cells where it serves as a cofactor for thrombin. Thrombomodulin reduces blood coagulation by converting thrombin to an anticoagulant from a pro-coagulant enzyme. Cytoplasmatic membrane-bound thrombomodulin immunostaining is strongest in TCC sections with respect to SCC, adenocarcinoma, sarcoma, seminoma, teratoma, papillary carcinoma, CCC, and is independent of both grade and stage. Thrombomodulin immunostaining in tumour tissue sections are predominately membranous.
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