A recent nationwide, epidemiological study investigated the incidence and outcome of severe traumatic brain injury (TBI) in Switzerland. The characteristics and the outcome of the patients with severe TBI at the Trauma Center of the University Hospital in Berne do not differ from other hospitals in industrialized countries. Young patients with a severe TBI, often caused by road traffic accidents, usually have a higher overall ISS and die within the first days post-injury. If they survive, they have a favorable outcome. Falls were the most frequent accident mechanism in elderly patients. Although they caused less severe injuries than RTA or other accidents, they were associated with higher but late mortality in this population.