Skeletal muscle bulk and strength are now becoming important therapeutic targets in exercise therapy. In order to get more muscle bulk and strength, we have to perform high-intensity resistance training with mechanical load greater than 65% of one repetition maximum (1 RM) . However, such intensive loads could not be often applied for weak subjects. In recent years, several lines of studies have provided the compelling data showing that low-intensity resistance training with blood flow restriction (BFR) leads to muscle hypertrophy and strength increase, and results in adaptations equal to those of high-intensity resistance training . The researchers suggested that the supplementation of low-intensity resistance exercise with BFR might provide additional stress and enhanced recruitment in the skeletal muscle fibers, but the exact details were not clarified.