alexa Renoprotection by hydrogen sulfide in hyperhomocysteinemia

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Renoprotection by hydrogen sulfide in hyperhomocysteinemia

Homocysteine (Hcy) is a sulfur-containing amino acid, which forms as an intermediate during methionine metabolism. High levels of plasma Hcy, also known as hyperhomocysteinemia (HHcy), are always associated with kidney insufficiency [4,5,26,31]. Results from recent studies have indicated that HHcy downregulates hydrogen sulfide (H2S) level and reduces endothelial nitric oxide synthase (eNOS) [18,22]. In addition, through imbalance of matrix metalloproteinases (MMP) and tissue inhibitor of metalloproteinases (TIMP), Hcy accumulates extracellular matrix (ECM) protein in the glomerulo-tubulointerstitial space [21,23,24]. These contribute to renovascular remodeling including renal fibrosis and dysfunction. Although Hcy is known for independent vascular risk factor, the mechanism of renal fibrosis in HHcy is largely unknown. In the tissue, Hcy however metabolizes by three endogenous enzymes: cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST) to produce H2S, a gaseous molecule of tremendous biological importance. This editorial highlights some of the recent updates and future directions of renoprotection by H2S in HHcy.

 

Sen U (2011) Renoprotection by hydrogen sulfide in hyperhomocysteinemia. Anatom Physiol 1:e111.

 

https://www.omicsonline.org/renoprotection-by-hydrogen-sulfide-in-hyperhomocysteinemia-2161-0940.1000e111.php?aid=3369

 

 

 
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