A healthcare provider is any person working in any health facilities is at the risk of coming in contact with contaminated medical materials and infective body products. The risk of HIV infection increases if a percutaneous injury; needle stick or medical sharp injuries, or contamination of break in skin or mucus membrane has occurred. The risks differ with different exposures. Health care providers are in constant risk of exposure to Human Immunodeficiency Virus (HIV)during their routine practice. This makes it paramount to evaluate their knowledge, attitude and practice of Post-Exposure Prophylaxis (PEP). Since this will determine their likely line of action if exposed to HIV.