Objectives: To assess student knowledge and ethical decision-making regarding legal and ethical principles and their application to drug information practice scenarios and to describe an active learning strategy designed to engage students in a large group lecture classroom based forum. Methods: Students are provided 6 drug information practice based scenarios and are asked if they would provide information/counseling to the inquirer based on the background provided. The scenarios are intended to stimulate classroom discussion and interactivity and focus on a legal and/or ethical obligation of pharmacists in the practice of drug information. Results: The survey instrument is a written questionnaire that is used as a participation required quiz although individual answers are not graded. Results from the class are presented in aggregate for each question. One thousand and ten students have completed the exercise from 2004 to 2013. Conclusions: This exercise incorporates active learning into a drug information course and assesses student knowledge and decision-making on legal and ethical them.