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Bullous Pemphigoid (BP) is an autoimmune blistering disease of the skin, which typically appears in the elderly with a peak incidence in the seventh decade. The incidence of BP seems to be equal in both genders and no known ethnic or racial predilection was detected. Among adults the reported incidence of BP varies from 6.6 cases per million people per year in France and Germany to 43 cases per million people per year in the United Kingdom, among infants and children the incidence is much rarer.BP is a chronic disease characterized by spontaneous exacerbations and remissions. Within 2.5 to 6.0 years about one-half of the treated patients are found in remission, nevertheless it might be fatal particularly when lesions are generalized.
The clinical manifestations of adult BP include tense blisters that following rapture leave shallow erosions. Oral cavity involvement is observed in 10 to 35% of the patients, mainly on the buccal mucosa. In infantile BP the blisters tend to occur more frequently on the palms, soles, face and rarely affect the genital area.
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