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Rabies is a worldwide problem, and the case is most severe in developing countries where cell culture anti-rabies vaccines are unaffordable or the available nervous tissue-derived vaccines are of questionable immunogenicity and may cause neurological complications. The aim of this research was to study cross protection of local rabies virus isolates with Evenyl Roktincki Abelseth (ERA) based cell culture anti-rabies vaccine produced in Ethiopia and to develop challenge virus from local isolates. The viruses were isolated from rabid dogs’ brains and human saliva, and adapted on Swiss albino mice and cell lines. Cross protection with ERA based vaccine was studied by in vivo and in vitro methods.
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