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Two male aged 37 years and 29 years presented with generalized itching followed by thickening and reddening of whole body for 3 and 6 months respectively. On examination generalized erythroderma, lymphadenopathy and hepato-splenomegaly were found. In both cases leucocyte count was high and of which 80-90% were morphologically Sezary cells. Peripheral blood absolute CD4+ lymphocytes were very high in both the cases. Skin biopsy showed dense infiltrate of lymphocytes in the dermis with intraepidermal collection of lymphocytes. Bone marrow was infiltrated with Sezary cells.
citation:
https://www.omicsgroup.org/journals/two-young-men-with-leonine-facies-and-generalized-itching-two-case-reports-of-sezary-syndrome-2329-6771.1000123.php?aid=33614
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