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“What does laser do on the retina?” “It is easy. It just destroys the RPE and surrounding tissues including photoreceptors.” “For what?” “to reduce oxygen consumptions mainly by photoreceptor outer segments in ischemic diseases, sometimes to coagulate retinal aneurisms, and to strengthen the retinal adhesion around the retinal holes or tears in order to avoid progression of retinal detachment”. It was the almost perfect answer, even still not completely proven, at least it was the enough knowledge in daily clinical practice before. But today, we are facing to the necessity to know more in detail, for example, “What happens if the RPE cells are just warmed up to 45°C for 0.1s?”, which we have almost never needed to consider before.