The failure to find a vaccine against HIV/AIDS has been attributed to numerous factors including the diversity and mutability of the virus and the lack of a good animal model. Current vaccine testing on NHPs has not only failed to predict human response, but has resulted in vaccines that ultimately proved harmful to humans. This is obviously a suboptimal record of accomplishment. Gamble and Matthews have noted the importance of this, stating: “Until a model can be derived that will allow for observation of each stage of infection, progression of disease, and response of the immune system in a way that is comparable to this process in humans, we will not be able to logically predict which vaccine candidates should be moved forward to clinical trials”. I will argue that even if a model could be developed that reproduced those human manifestations and mechanisms; it would be inadequate for predictive purposes.