alexa Autoimmunity

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Autoimmunity of skewed X inactivation may in part explain high prevalence of autoimmune diseases in women. Human X chromosome encodes approximately 7% of the total microRNAs identified. Recent studies have implicated over expression of X-linked miRNA in women affected by the autoimmune diseases. Potential biological targets of them include critically important genes such as FOXP3, CTLA-4, PDCD1 and, members of CBL and SOCS family ubiquitin ligases, which play an important role in the immune suppressive mechanisms and maintenance of tolerance. X-linked miRNA mediated post transcriptional suppression of immunosuppressive genes is an open area of study with potential to better understand why women develop many autoimmune disorders more often than men. For more information, kindly follow the link:

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