A liver biopsy is a procedure in which a small needle is inserted into the liver to collect a tissue sample. The tissue is then analyzed in a laboratory to help doctors diagnose a variety of disorders and diseases in the liver.
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease worldwide and its prevalence continues to increase with the growing outbreak of obesity. NAFLD includes wide spectrum of diseases from fully benign simple steatosis to steatohepatitis, which could progress to liver cirrhosis and hepatocellular carcinoma. Liver biopsy is considered as the gold standard for assessing disease severity.
Patients and Methods
Serum concentrations of hyalurinic acid (HA), cytokeratine-18 fragments, TIMP1 and P3NP were measured and index Hepascore was calculated in 88 patients with NASH indicated for liver biopsy; in 10 patients measurement of hepatic venous pressure gradient was performed.
The values of examined parameters were significantly elevated in patients with NASH compare to controls. Significant difference
in HA, Hepascore and other parameters was found between cirrhosis and all other fibrosis stages (p<0.05).