Eighteen Clashes, also known as Eighteen Incompatibilities, is an equivocal rule of Chinese medicine. It is about the prescription, contradiction of eighteen drug pairs such as Radix Glycyrrhizae against Radix Euphorbiae Pekinensis, Radix Aconiti against Bulbus Fritillariae Cirrhosae, Radix et Rhizoma Veriatri Nigri against Radix Ginseng, and so on. This rule is always followed by a majority of doctors of traditional Chinese medicine (TCM), and is one of the major parts of the Chinese herbal property theory. Most of the TCM doctors believe that using anti-drugs simultaneously could generate or enhance the toxicity and damage to human body, and thus they emphasize that the drugs which contradict each other cannot be used in the same prescription. The Eighteen Clashes was compiled into pithy formula and has been passed down for nearly a thousand years since Jin Dynasty and Yuan Dynasty.

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