Major depressive disorder (MDD) is a psychiatric disorder characterized among others by prolonged depressed mood, a loss of interest in enjoyable activities, psychomotor retardation and various cognitive symptoms. Although exact numbers of prevalence may differ between various western countries, partly due to a social taboo of the illness, the life-time prevalence in the USA and Western Europe lies around 15%. Women are more likely to be struck by MDD than men, often with a first episode between 30-40 years of age, with a smaller second peak around 50-60 years of age. Although MDD may appear as a “stand alone” disease, 33% of patients with a chronic illness report symptoms of major depression.
Citation: Verbeek EC, Bevova MR, Hoogendijk WJG, Heutink P (2014) The Genetics of MDD ï¿½ A Review of Challenges and Opportunities. J Depress Anxiety 3:150.