alexa Human Genome: Repair of Accidental DNA Double-Strand Breaks

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Human Genome: Repair of Accidental DNA Double-Strand Breaks

Human cells have evolved two fundamentally different mechanisms for repairing chromosomal DSBs, homologous recombination (HR) and non-homologous end-joining (NHEJ). NHEJ not only repairs accidental (non-physiological) DSBs, but is also essential for rejoining physiological DSBs that arise in the process of V(D)J recombination in B and T lymphocytes and class switch recombination in mature B cells.

 

Citation: Adachi N, Saito S, Kurosawa A (2013) Repair of Accidental DNA Double- Strand Breaks in the Human Genome and Its Relevance to Vector DNA Integration. Gene Technology 3:e107.

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