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The advances in knowledge about production and stability of dispersed systems enable the development of differentiated vehicles such as nanoemulsions and nanoemulgels, which have been effectively used to increase the bioavailability and improve the stability of the active ingredients. Now a days there is an intensely usage of natural bioactive materials as medicinal agent in pharmaceutical industries. Swietenia macrophylla oil is used due to the bioactivity of different parts of the plant as anti-inflammatory, anti-mutagenicity, anti-tumor. SM oil Nanoemulgels were prepared by incorporating nanoemulsion with hydrogel.