SNAREs (N-ethylmaleimide-sensitive factor adaptor protein receptors) are small polypeptides characterized by a specific domain called SNARE motif. This can form a coiled-coil structure and interacts with other SNARE motifs via hetero-oligomeric interactions to form highly stable protein-protein interactions. The derived complex is called SNARE-complex and allows membrane fusion. SNAREs also interact with several proteins acting as regulators of this complex formation. Their indubitable importance was certified by the Nobel Prize 2013 for Medicine, awarded to the scientist who clarified the way they interact, James E. Rothman. Nobel Prize was shared with the other two scientists contributing to the description of vesicle traffic, Randy W. Schekman, and Thomas C. Südhof, but SNAREs certainly have central role in the determination of traffic specificity. Recently the model that won the Nobel was enormously enriched by further discoveries, about SNAREs in particular. In fact SNAREs stoichiometry reveals that they are more abundant than required for membrane traffic.