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The key of treating T1D is to replenish the lost beta cells or their products, insulin. Much effort has been made into exploring beta cell regeneration so that the new insulin producing cells can replenish the lost beta cells caused by autoimmune destruction. Though pancreatic beta cells which originated from the same ancestor showed no differences in gene expression profile, it was recently revealed that only a small group of specialized beta cells will regain the potential to proliferate under certain conditions.
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