alexa The Relation between Sterilization Validation and Nosocomial Infection

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The Relation between Sterilization Validation and Nosocomial Infection

Sterilization validation is so often considered to attain SAL (Sterility Assurance Level) of 10-6, but this is not correct. The correct is to attain both simultaneously SAL of 10-6 and material and functional compatibility of the sterilized devices. SAL of 10-6 can be easily attained by using BI (Biological indicator) and D (decimal reduction value). For example it is 12D as an overkill method. On the contrary, it is quite hard to attain material and functional compatibility to the products exposed up to SAL of 10-6. One typical example is the sterilization of endoscope. Endoscope is repeatedly used after sterilization, but the endoscope part to carry out biopsy is deteriorated after a few times use. So, sterilization is not conducted and HClO (pH 4-6) or only water washing is so often conducted in the exact healthcare facilities. By these methods purion, hepatitis virus or H. pylori is infected between human to human during endoscope inspection. Most easy method for sterilization of endoscope is gamma-ray irradiation. It is true that it can attain SAL of 10-6 in ease, but most often material and functional compatibility cannot attain. According to the author’s experience (already reported), for example, artificial dialyzer was sterilized with gamma-ray up to SAL of 10-6, material degraded and toxic and endocrine disrupter of bisphenol A is produced. Resemble phenomenon can be observed when exposed to polyurethane, polyurethane degraded and toxic 4,4`-methylene dianiline (MDA) produced at significant amount.

Citation: Shintani H (2013) The Relation between Sterilization Validation and Nosocomial Infection. Chem Sci J 4:073. doi: 10.4172/2150-3494.1000073

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