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Several epidemiological studies have shown that the potential of human skin melanocytes for developing melanocytic tumors in response to mitogenic stimuli differs according to anatomical location. However, despite recent advances, the proliferative responses of different human skin melanocytes remain unknown. The complex, multifactorial, and heterogeneous process of melanocyte differentiation occurs throughout life, from embryonic development to adulthood, and it appears to involve both genetic and environmental factors.
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