The Coccidioidomycosis is a deep mycosis caused by two dimorphic fungi, Coccidioides immitis and Coccidioides posadasii characterized by diverse clinical manifestations. This fungus is found in the southern of the United States and Northern Mexico. It causes an infectious disease but that is not contagious. Skin involvement in coccidioidomycosis is usually secondary to disseminated infection. Primary cutaneous coccidioidomycosis is rare clinical condition and may be misdiagnosed as tuberculosis, leprosy, and presented as ulcers, erythematous lesion, verrucous granuloma, intact nodules, and subcutaneous abscess. The prevalence of primary extrapulmonary disease is 0.5%, therefore, a high degree of suspicion is needed to diagnose the cutaneous form of the disease. We present five cases of primary cutaneous coccidioidomycosis.