Oxidative stress has been recommended as a contributory factor in complication and progression of diabetes. The aim of the study was to evaluate the effects of pomegranate on body weight and histopathology of the steptozotocin–nicotiamide (STZ-NA) generated oxidative stress induced diabetic rats. Thirty-two male Sprague- Dawley rats were randomly divided into non-diabetic, diabetic untreated and diabetic treated with pomegranate and Glibenclamide. Experimental diabetes was induced by a single intraperitoneal (i.p) administration of STZ 60 mg/kg body weight (b.w), 15 minutes after the i.p injection of NA (120 mg/kg b.w). Histopathological analyses were conducted on the liver and kidney tissues. While the body weight significantly decreased in the diabetic control group, however it was a significant increase in the diabetic treated group (P<0.05). Destruction of the liver architecture of the hepatocytes in the diabetic group showed the signs of necrosis, degeneration, dilatation, and inflammation in the central vein and blood vessels. In the kidney, shrinkage and lesion in Bowman’s capsule were observed. Pomegranate acted as an antioxidant thereby preventing oxidative damage in the diabetic liver and kidney.