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Mycobacterium tuberculosis, the causative agent of tuberculosis is a facultative intracellular pathogen that infects and resides in humans and is a leading infectious cause of death in many parts of the world with a worrying increase in transmission and resistance to drugs. This pathogen is generally transmitted by inhalation of infectious aerosols into the lung with deposition in the terminal bronchioles and alveoli. Most affected persons stand an effective immune response that might controls this pathology but does not totally eradicate the primary tuberculosis infection and the reactivation of persistent M. tuberculosis later in life occur frequently in active tuberculosis cases.
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