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How does chronic inflammation contribute to depression? Do abnormalities in joint flexibility contribute to anxiety? What are the salutary factors that may prevent or mitigate pathogenesis? These types of general questions gain salience as the models of medical and psychiatric pathologies converge on a final common pathway model. According to this model, many different factors – genetic, epigenetic, experiential and acquired memories (i.e., information-memes), and stress interact in the balance between health and illness.
Citation: Leigh H (2014) Toward an Integrative Perspective for Health and Disease. J Depress Anxiety 3:e105.
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