The dietary glucose cannot cross easily the lipid intestinal bilayer of enterocyte. So, specific transporters are required for glucose intestinal absorption. The Na+/glucose co-transporter (SGLT1) at the enterocyte apical membrane transports glucose into the cell against its concentration gradient. Also, a facilitative Glucose Transporter (GLUT2), transports sugars across the basolateral membrane to the blood. Some studies show evidences that GLUT2 can also be recruited to the Brush-Border Membrane (BBM) in the presence of high glucose concentration in the lumen and can participate in the intestine glucose absorption process.
Citation: Postal BG, Guesser SM, Kappel VD, Ruani AP, Zamorano NS, et al. (2014) Mechanism of Action of Nutraceuticals on Intestine to Ameliorate Glucose Homeostasis: Follow-up Studies by an In Situ Approach. J Cell Sci Ther 5:162