Human infertility affects approximately 10% of couples worldwide and has led to the development of a suite of clinical laboratory techniques designed to combat such conditions, collectively referred to as ‘Assisted Reproductive Technology’ (ART). Such methodology has subsequently resulted in the birth of more than 4.6 million babies worldwide. Infertility may arise as a result of individual male or female factors, a combination of both, or for unknown reasons (idiopathic infertility). While clinical and laboratory aspects of ART have been significantly refined since their first successful clinical application, global pregnancy and live birth rates from ART rarely exceed ~40%.
Citation: Kashir J, Yelumalai S, Jones C, Coward K (2012) Clinician-Induced (Iatrogenic) Damage Incurred during Human Fertility Treatment: Detrimental Effects upon Gamete and Embryo Viability and the Potential for Epigenetic Risk. Human Genet Embryol 2:e105