alexa BTK’s Remarkable Efficacy in B Cell Malignancies

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BTK’s Remarkable Efficacy in B Cell Malignancies

Bruton’s tyrosine kinase (BTK), a member of the Tec family of protein tyrosine kinases (PTKs), plays a vital and diverse function in many cellular processes. BTK is expressed throughout B cell development, widely participating in multiple signal pathways.Those pathways play critical functions in cell proliferation, development, differentiation, survival, and apoptosis. Targeting BTK has achieved remarkable efficacy in B cell malignancies, multiple myeloma and related bone disease.

 

Citation: Liu Y, Zhou G, Zhang B, Liu Y (2013) Bruton’s Tyrosine Kinase: Structure and Functions, Expression and Mutations. Gene Technology 2:106.

 
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