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Bruton’s tyrosine kinase (BTK), a member of the Tec family of protein tyrosine kinases (PTKs), plays a vital and diverse function in many cellular processes. BTK is expressed throughout B cell development, widely participating in multiple signal pathways.Those pathways play critical functions in cell proliferation, development, differentiation, survival, and apoptosis. Targeting BTK has achieved remarkable efficacy in B cell malignancies, multiple myeloma and related bone disease.
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