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The use of zebrafish allows one to combine the ability to perform behavioral assays with HTS. Zebrafish have been used to screen for potential neuroprotective compounds in a zebrafish model of Parkinson’s. There is great potential to develop zebrafish disease models and behavioral assays which can be used in HTS for drugs which affect dopaminergic pharmacology. The advantages of zebrafish for pharmaceutical screening can be exploited to equilibrium existing cell culture and mouse studies to test and develop new therapeutic compounds.
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