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Current guidelines for the diagnosis and management of hypertension have defined cardiovascular risk by the elevation of systolic blood pressure (SBP) and/or the elevation of diastolic blood pressure (DBP). Pulse pressure amplitude is a marker of myocardial infarction risk. Pulse pressure can be defined as the variation in blood pressure occurring in an artery during the cardiac cycle; the difference between systolic and diastolic pressures. Physiologically, both pressures increase throughout life due to the increase of stroke volume and/or peripheral vascular resistance (PVR). When the pulse pressure amplitude is used for risk level evaluation at least sex should be taken into account. Studies show that increased pulse pressure amplitude is greater risk for men than for women. Higher PP is shown to be related to smoking, diabetes mellitus, dyslipidemia, hyperhomocysteinemia, obesity and power sports activity.
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