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Epidemiological investigations have suggested that the consumption of fruits and vegetables is associated with a lower risk of many different types of human cancer including oropharyngeal. The protective effects of fruits and vegetables are thought to be related to their cancerpreventive components such as fiber, flavonoids, and polyphenols. Avocado extracts and isolated individual phytochemicals have shown anticancer activity in various types of human cancer cell lines such as oral, breast, and prostate in which extracts and individual phytochemicals may act by inhibiting cancer cell proliferation and inducing apoptosis.