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omicsonline.org/sonography-for-assessment-of-elbows-in-hemophilic-children-a-systematic-protocol-2161-1149.S2-004.pdf Recurrent hemarthrosis in hemophiliacs leads to synovial inflammation and proliferation associated with absorption of hemosiderin and red cell products. The breakdown of extravasated blood from synovial vessels ultimately leads to synovitis, cartilage loss and subchondral bone irregularity. The age of onset and frequency of hemarthrosis is most frequently determined by the level of factor deficiency, which can be severe (factor VIII or IX baseline activity ≤ 1%), moderate (residual activity 2%-5%) or mild (residual activity > 5%). However, it typically starts in the first and second decades of life. For more information about the article, please go through the above link
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