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The natural bioproduct of silk viz. the Silk Protein, Sericin, having several beneficial qualities viz., Anti-bacterial, Antioxidant, Wound healing, Anti-tumor activity etc. has been chosen to appraise its potential as “Cognitive enhancer”, AD-induced rat model by directing trials on Morphometric changes along with Learning and Memory efficiency; on Cholinergic system, Antioxidant system and Histological aspects in particular brain regions of control and experimental rats.