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Stem Cells and the Translational Control of Differentiation
Stem cells have been proposed as a promising source for cell therapy. Understanding the biological processes that commit stem cells to differentiate into a particular cell type is essential for the successful repair of injured tissue, and even for whole organogenesis. Cellular differentiation can be modeled as a network of regulatory circuits that direct various steps of gene expression and mediate the spatiotemporal control of a cell’s proteome. Several data supports the idea that a significant percentage of genes have their expression controlled at the translational level during stem cell commitment and differentiation.
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