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As every investigator in integrative medicine, I am often asked does this supplement have activity in human, is it safe and for me often does it prevent/treat/cause cancer? While the peer reviewed literature in integrative medicine and in particular herbal and nutritional supplements has grown exponentially in the past two decades, the clarity of an answer is as clear as mud in many cases. In my opinion the crux of the issue is that there are limited guidelines in how to go about designing appropriate pre-clinical studies for herbal and nutritional studies. From a pharmacology perspective, one of the primary issues contributing to the inconsistency and conflicting data is how the “dose” for the study is selected.
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